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Proceedings Paper

Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)

Paper Abstract

Nearly all benchtop studies of corneal biomechanics have relied on protocols which stiffen the cornea, such as riboflavin-UV crosslinking, as a way of providing contrast and validation of biomechanical measurements. However, there are strong clinical motivations to detect softening of the cornea. In this work, we present the evidence that phase-decorrelation OCT (PhD-OCT) is able to detect a small degree of corneal softening due to enzymatic digestion. This benchtop study supports the idea that PhD-OCT may detect keratoconus and early ectasia clinically.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180W (9 March 2020); doi: 10.1117/12.2546557
Show Author Affiliations
Brecken J. Blackburn, Case Western Reserve Univ. (United States)
John P. Murray, Case Western Reserve Univ. (United States)
Matthew R. Ford, Cleveland Clinic (United States)
Michael W. Jenkins, Case Western Reserve Univ. (United States)
William J. Dupps Jr., Cleveland Clinic (United States)
Andrew M. Rollins, Case Western Reserve Univ. (United States)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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