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Proceedings Paper

Quantitative measurements of intraocular structures including subretinal microinjection bleb volumes using intraoperative optical coherence tomography (Conference Presentation)

Paper Abstract

Microscope-integrated optical coherence tomography (MIOCT) systems allow for 4D visualization of thin, semi-transparent structures during ophthalmic microsurgery. While these visualizations have greatly increased the information available to surgeons, new surgical techniques, such as subretinal injections of gene therapies, would benefit from quantitative measurements of structures imaged using OCT. Calibration of true scan dimensions in OCT is complicated by inter-patient ocular variability as well as poor control of scanner-patient alignment. We introduce novel measurement techniques for calibration and de-warping of OCT imagery which allows for accurate measurement of intraocular structures including subretinal microinjection bleb volumes in the ocular posterior segment.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280H (9 March 2020); doi: 10.1117/12.2546504
Show Author Affiliations
Jianwei D. Li, Duke Univ. (United States)
William Raynor, Duke Univ. Medical Ctr. (United States)
Ananth Sastry M.D., Duke Univ. Medical Ctr. (United States)
Al-Hafeez Dhalla, Duke Univ. (United States)
Cynthia Toth M.D., Duke Univ. Medical Ctr. (United States)
Christian Viehland, Duke Univ. (United States)
Lejla Vajzovic M.D., Duke Univ. Medical Ctr. (United States)
Joseph A. Izatt, Duke Univ. (United States)
Duke Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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