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Proceedings Paper

Enhanced model for predicting femoral fracture toughness in ovariectomized mice using Raman spectroscopy and x-ray imaging (Conference Presentation)

Paper Abstract

Fracture toughness, a bone’s resistance to breaking, is typically measured via invasive mechanical tests. In this ex vivo study on mouse femurs, four Raman spectral features associated with bone properties were significantly correlated to fracture toughness using a partial least squares regression model. By including parameters measured from dual-energy absorptiometry and micro-computed tomography in the model, fracture toughness predictions on ovariectomized mice were significantly lower than a control cohort’s. This shows that meaningful estimates of fracture toughness can be estimated using input parameters obtained non-destructively.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 112360U (9 March 2020); doi: 10.1117/12.2546477
Show Author Affiliations
Christine M. Massie, Univ. of Rochester (United States)
Emma Knapp, Univ. of Rochester Medical Ctr. (United States)
Keren Chen, The Institute of Optics, Univ. of Rochester (United States)
Hani A. Awad, Univ. of Rochester (United States)
Univ. of Rochester Medical Ctr. (United States)
Andrew J. Berger, The Institute of Optics, Univ. of Rochester (United States)
Univ. of Rochester (United States)


Published in SPIE Proceedings Vol. 11236:
Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry
Wolfgang Petrich; Zhiwei Huang, Editor(s)

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