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Proceedings Paper

Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems
Author(s): Elif Kayaalp Nalbant; Wenqiang Liu; Hande Pehlivan; Shailee Shah; Anessa Puskar; Meghna Sampath; William F. Mieler; Jennifer J. Kang-Mieler; Kenneth M. Tichauer
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Paper Abstract

Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified “adiabatic approximation to the tissue-homogeneity model” was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.

Paper Details

Date Published: 19 February 2020
PDF: 4 pages
Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121823 (19 February 2020); doi: 10.1117/12.2546442
Show Author Affiliations
Elif Kayaalp Nalbant, Illinois Institute of Technology (United States)
Wenqiang Liu, Illinois Institute of Technology (United States)
Hande Pehlivan, Illinois Institute of Technology (United States)
Shailee Shah, Illinois Institute of Technology (United States)
Anessa Puskar, Illinois Institute of Technology (United States)
Meghna Sampath, Illinois Institute of Technology (United States)
William F. Mieler, Univ. of Illinois at Chicago (United States)
Jennifer J. Kang-Mieler, Illinois Institute of Technology (United States)
Kenneth M. Tichauer, Illinois Institute of Technology (United States)


Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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