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Proceedings Paper

Kernel principle component analysis applied to Raman spectra to differentiate drugs administered to rabbit cornea in blind study
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Paper Abstract

Scanning confocal Raman spectroscopy was applied for detecting and identifying topically applied ocular pharmaceuticals on rabbit corneal tissue. Raman spectra for Cyclosporin A, Difluprednate, and Dorzolamide were acquired together with Raman spectra from rabbit corneas with an unknown amount of applied drug. Kernel principle component analysis (KPCA) was then used to explore a transform that can describe the acquired set of Raman spectra. Using this transform, we observe some spectral similarity between cornea spectra and Cyclosporin A, with little similarity to Dorzolamide and Difluprednate. Further investigation is needed to identify why these differences occur.

Paper Details

Date Published: 19 February 2020
PDF: 7 pages
Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 1121907 (19 February 2020); doi: 10.1117/12.2546431
Show Author Affiliations
Sean P. O'Connor, Texas A&M Univ. (United States)
Eddie M. Gil, Texas A&M Univ. (United States)
SAIC Corp. (United States)
Mark A. Keppler, Texas A&M Univ. (United States)
SAIC Corp. (United States)
Marlan O. Scully, Texas A&M Univ. (United States)
Baylor Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 11219:
Visualizing and Quantifying Drug Distribution in Tissue IV
Kin Foong Chan; Conor L. Evans, Editor(s)

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