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Proceedings Paper

Quantitative phase digital holographic microscopy combined with stem cell technology for identifying cell biomarkers of neurodevelopmental brain disorders including schizophrenia (Conference Presentation)

Paper Abstract

The recent developments in stem cell biology especially the generation of induced pluripotent stem cells (iPSCs) has made possible the development of in vitro cellular models of developmental brain disorders including schizophrenia. Within this framework, we will present how quantitative phase imaging and in particular quantitative phase digital holographic microscopy (QP-DHM), as a label-free technique is able to study these in vitro cellular models and identify both some pathophysiological processes and cell biomarkers related to developmental brain disorders. This will be illustrated by the exploration with QP-DHM of human neuronal networks derived from iPSCs coming from patients suffering from schizophrenia.

Paper Details

Date Published: 11 March 2020
Proc. SPIE 11249, Quantitative Phase Imaging VI, 112490V (11 March 2020); doi: 10.1117/12.2546407
Show Author Affiliations
Pierre P. Marquet, CERVO Brain Research Ctr. (Canada)
François Paquet-Mercier, CERVO Brain Research Ctr. (Canada)
Chloé Martel, CERVO Brain Research Ctr. (Canada)
Catherine Giroux, CERVO Brain Research Ctr. (Canada)
Carine Ben Adiba, Joint International Research Unit in Child Psychiatry, Univ. de Lausanne / Univ. Laval (Switzerland)
Ana-Sofia Correia, CERVO Brain Research Ctr. (Canada)
Émile Rioux Pellerin, CERVO Brain Research Ctr. (Canada)
Jean-Xavier Giroux, CERVO Brain Research Ctr. (Canada)
Marie-Eve Crochetière, CERVO Brain Research Ctr. (Canada)
Erik Bélanger, CERVO Brain Research Ctr. (Canada)
Pascal Jourdain, Joint International Research Unit in Child Psychiatry, Univ. de Lausanne / Univ. Laval (Switzerland)

Published in SPIE Proceedings Vol. 11249:
Quantitative Phase Imaging VI
Yang Liu; Gabriel Popescu; YongKeun Park, Editor(s)

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