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Proceedings Paper

Iodide-doped gold/silver hybrid nanoparticle for increased sensitivity to reactive oxygen species using photoacoustic imaging (Conference Presentation)
Author(s): Yash Mantri; Barak Davidi; Jesse V. Jokerst

Paper Abstract

Bacterial infections lead to high oxidative stress due to production of reactive oxygen species like H2O2 and ONOO- inducing cell damage and death. ROS are a short-lived species making direct, precise and real time measurements difficult. Ag+ is a known bactericidal, disrupting metabolism and disulfide bond formation. In this work we synthesized a thernostic nanoparticle that can measure ROS concentrations and release Ag+ in the presence of ROS. The iodide-doped gold/silver hybrid nanoparticle is 10X more sensitive to H2O2 as compared to silver coated gold nanorods.

Paper Details

Date Published: 6 March 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112401A (6 March 2020); doi: 10.1117/12.2546405
Show Author Affiliations
Yash Mantri, Univ. of California, San Diego (United States)
Barak Davidi, Fairfield Univ. (United States)
Jesse V. Jokerst, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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