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Proceedings Paper

Imaging the molecular composition-specific tissue biomechanics at high frequency with Brillouin-Raman microscopy (Conference Presentation)
Author(s): Francesca Palombo

Paper Abstract

Biological tissues have complex structures, dynamics and interactions between their constituents. When probing mechanical properties, differences are observed across spatial and temporal scales owing to the tissue viscoelastic response. Quasistatic mechanical testing, ultrasound and AFM-based techniques provide the traditional approach to measure stiffness based on the Young’s modulus. A novel technique in the fields of biophotonics and biomechanics is Brillouin spectroscopy, which is a contactless optical method to detect viscoelastic properties from the propagation of thermally-driven acoustic waves or phonons at high frequencies, GHz. A longitudinal elastic modulus is detected, whose significance in mechanobiology and clinical settings is currently emerging.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112520J (10 March 2020); doi: 10.1117/12.2546396
Show Author Affiliations
Francesca Palombo, Univ. of Exeter (United Kingdom)

Published in SPIE Proceedings Vol. 11252:
Advanced Chemical Microscopy for Life Science and Translational Medicine
Ji-Xin Cheng; Wei Min; Garth J. Simpson, Editor(s)

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