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Proceedings Paper

Multispectral nanoparticle tracking analysis for the real-time characterization of amyloid-β self assembly in vitro (Conference Presentation)
Author(s): Colman Moore; Ryan Wing; Jesse V. Jokerst

Paper Abstract

There has been little headway against Alzheimer’s disease despite decades of research into causes, conditions, and cures. Much of this effort has focused on the amyloid beta protein; however, it remains unclear whether it plays a causative or correlative role. Amyloid beta is notoriously difficult to study, and many of the current tools to monitor oligomerization and fibril formation are inadequate and are incapable of measuring the subtle details of plaque formation and deformation. Our preliminary data suggests that multispectral nanoparticle analysis can monitor the sigmoidal self-assembly (R2 = 0.94) of physiologically relevant populations of amyloid beta aggregates in real-time with single fibril resolution.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121603 (9 March 2020); doi: 10.1117/12.2546360
Show Author Affiliations
Colman Moore, Univ. of California, San Diego (United States)
Ryan Wing, Univ. of California, San Diego (United States)
Jesse V. Jokerst, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 11216:
Multiscale Imaging and Spectroscopy
Paul J. Campagnola; Kristen C. Maitland; Darren M. Roblyer, Editor(s)

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