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Proceedings Paper

Heartbeat OCE: Corneal biomechanical response to simulated heartbeat pulsation
Author(s): Achuth Nair; Manmohan Singh; Salavat R. Aglyamov; Kirill V. Larin
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Paper Abstract

The biomechanical properties of the cornea can be an important biomarker for assessing tissue health. In this work, we evaluated cornea biomechanical properties during intraocular pressure fluctuation simulating heartbeat induced corneal pulse. This method results in a more physiologically relevant assessment of tissue mechanics, and thus diverges from typical elastography techniques that rely on externally induced deformation. Optical coherence tomography is used to detect displacements in the cornea as IOP is cycled. The axial strains within the cornea are calculated from these displacements, so that dynamic changes in stiffness can be determined. The results indicate a gradient in axial displacement within the cornea and illustrate a distinct difference in strain between the untreated and crosslinked tissues. This suggests that heartbeat OCE may be a useful technique in assessing stiffness of the cornea.

Paper Details

Date Published: 13 February 2020
PDF: 5 pages
Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 1124205 (13 February 2020); doi: 10.1117/12.2546196
Show Author Affiliations
Achuth Nair, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Salavat R. Aglyamov, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)


Published in SPIE Proceedings Vol. 11242:
Optical Elastography and Tissue Biomechanics VII
Kirill V. Larin; Giuliano Scarcelli, Editor(s)

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