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Proceedings Paper

longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Conference Presentation)

Paper Abstract

Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in abnormal brain states, longitudinal, simultaneous mapping of neural activity and hemodynamics is highly desired but challenging to achieve. Here, we report the development of a multimodal neural platform that realize long-term, spatially-resolved tracking of intracortical neural activity and cerebral blood flow in the same brain regions. We demonstrate the powerful application of this multimodal platform in a mouse model of microinfarcts and reveal a pronounced, long-lasting neurovascular dissociation that depends on the ischemic severity.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11226, Neural Imaging and Sensing 2020, 1122618 (9 March 2020); doi: 10.1117/12.2546187
Show Author Affiliations
Fei He, Rice Univ. (United States)
Colin Sullender, The Univ. of Texas at Austin (United States)
Hanlin Zhu, The Univ. of Texas at Austin (United States)
Theresa Jones, The Univ. of Texas at Austin (United States)
Chong Xie, Rice Univ. (United States)
Andrew K. Dunn, The Univ. of Texas at Austin (United States)
Lan Luan, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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