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Proceedings Paper

Understanding opioid-induced metabolic changes in brain and neurons using label-free multimodal nonlinear optical imaging (Conference Presentation)

Paper Abstract

It is still unclear how neuronal metabolism is affected by opioids. We developed a multimodal nonlinear optical imaging platform that can resolve single neurons while monitoring endogenous metabolic molecules in a label-free manner. These capabilities enable investigation of morphine-induced metabolic changes in neurons. Additionally, mouse brain slices were used to study the effects of morphine on metabolism in the brain. We found that after morphine exposure, the nucleus accumbens area showed increased metabolic activity compared to the cerebral cortex. Further studies will reveal how opioids alter the metabolism of the brain and individual neurons at the sub-cellular level.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260O (9 March 2020); doi: 10.1117/12.2546179
Show Author Affiliations
Chi Zhang, Univ. of Illinois (United States)
Jaena Park, Univ. of Illinois (United States)
Carlos Renteria, Univ. of Illinois (United States)
Eric Chaney, Univ. of Illinois (United States)
Stephen A. Boppart, Univ. of Illinois (United States)

Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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