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Proceedings Paper

Hybrid photoacoustic and fluorescence endomicroscopy through a multimode fiber via transmission-matrix-based optical wavefront shaping (Conference Presentation)

Paper Abstract

One limitation of microendoscopy is the device footprint that should be minimal for many applications. Here we present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. With the use of a fast spatial-light modulator, it is possible to rapidly learn the transmission matrix during a prior calibration step. A focused spot can then be produced to raster-scan a sample at the distal tip of the fiber. Our setup provides both photoacoustic and fluorescence microscopic images of test samples in vitro (fluorescent beads and red blood cells) through a single multimode fiber.

Paper Details

Date Published: 11 March 2020
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Proc. SPIE 11248, Adaptive Optics and Wavefront Control for Biological Systems VI, 112480V (11 March 2020); doi: 10.1117/12.2546165
Show Author Affiliations
Sylvain Mezil, Lab. Interdisciplinaire de Physique, Univ. Grenoble Alpes (France)
CNRS (France)
Irène Wang, Lab. Interdisciplinaire de Physique, Univ. Grenoble Alpes (France)
CNRS (France)
Philippe Moreau, Lab. Interdisciplinaire de Physique, Univ. Grenoble Alpes (France)
CNRS (France)
Théodore Remark, Lab. Interdisciplinaire de Physique, Univ. Grenoble Alpes (France)
CNRS (France)
Antonio M. Caravaca-Aguirre, Lab. Intrdisciplinaire de Physique, Univ. Grenovle Alpes (France)
CNRS (France)
Emmanuel Bossy, Lab. Interdisciplinaire de Physique, Univ. Grenoble Alpes (France)
CNRS (France)


Published in SPIE Proceedings Vol. 11248:
Adaptive Optics and Wavefront Control for Biological Systems VI
Thomas G. Bifano; Sylvain Gigan; Na Ji, Editor(s)

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