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Proceedings Paper

Multi-fiber distributed temperature profiling in ex vivo magnetite nanoparticle-mediated laser tissue ablation
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Paper Abstract

Laser ablation (LA) has shown promising results in selective treatment of solid tumors. Recently, nanomaterials, in particular nanoparticles (NPs), have been proposed as mediators for laser tissue ablation due to their high optical absorption coefficients. In this work, we report distributed fiber optic temperature sensors for monitoring of NPmediated LA in ex-vivo porcine liver. This study aims at improving the outcomes of LA through magnetite NPsenhanced LA with in-situ thermal profiling. Such thermal profiling is achieved with optical backscatter reflectometer interrogating a set of custom-made MgO-doped optical fibers exhibiting enhanced scattering profiles. Fiber optic sensors, providing spatially resolved measurements, significantly outperform conventional thermocouples and imaging techniques. A minimally invasive LA setup is based on high power fiber coupled diode laser operating at 980 nm wavelength, with output power up to 30 W. Magnetite (Fe3O4) NPs are synthetized and locally injected within the tissue before performing LA. The sensing setup utilizes optical backscatter reflectometer that exploits Rayleigh backscattering to measure the temperature distribution with submillimeter spacing. Thermal maps, i.e. temperature distribution as a function of space and time, are reported highlighting thermal distribution within the ablated lesion and in off-target adjacent tissue. The influence of laser power and of NPs concentrations on the outcomes of LA is also investigated. Results demonstrate that injection of NPs into targeted area helps enhance conversion of light energy into thermal energy, thus increasing the efficacy of the ablation within the treated area, without overheating the adjacent off-target tissue.

Paper Details

Date Published: 20 February 2020
PDF: 6 pages
Proc. SPIE 11238, Optical Interactions with Tissue and Cells XXXI, 112380H (20 February 2020); doi: 10.1117/12.2546104
Show Author Affiliations
Madina Jelbuldina, Nazarbayev Univ. (Kazakhstan)
Aizahn Issatayeva, Nazarbayev Univ. (Kazakhstan)
Arman Aitkulov, Nazarbayev Univ. (Kazakhstan)
Sanzhar Korganbayev, Politecnico di Milano (Italy)
Aidana Beisenova, Nazarbayev Univ. (Kazakhstan)
Nazerke Kulmukhanova, Nazarbayev Univ. (Kazakhstan)
Dana Koshen, Nazarbayev Univ. (Kazakhstan)
Carlo Molardi, Nazarbayev Univ. (Kazakhstan)
Daniele Tosi, Nazarbayev Univ. (Kazakhstan)

Published in SPIE Proceedings Vol. 11238:
Optical Interactions with Tissue and Cells XXXI
Bennett L. Ibey; Norbert Linz, Editor(s)

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