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Proceedings Paper

Quantitative assessment of the three-dimensional microarchitecture of the human vocal fold using optical coherence tomography, two-photon excitation fluorescence microscopy, and second harmonic generation (Conference Presentation)
Author(s): Fouzi Benboujja; Christopher J. Hartnick

Paper Abstract

Phonation is a unique ability tightly connected to the vocal folds’ biomechanical properties. Unfortunately, radiological imaging modalities have insufficient resolution and contrast to assess the 3D vocal fold morphology, therefore limiting our understanding of the pathogenesis of laryngeal lesions. Herein, we investigate the three-dimensional human vocal fold fiber distribution and orientation with Optical coherence tomography (OCT), Two-photon excitation fluorescence (TPEF) and Second harmonic generation (SHG). The findings are summarized in a 3D model of the human vocal folds and suggest why vocal pathology occurs predominantly in discrete areas of the vocal fold.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11213, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2020, 112130I (6 March 2020); doi: 10.1117/12.2546063
Show Author Affiliations
Fouzi Benboujja, Harvard Medical School (United States)
Christopher J. Hartnick, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 11213:
Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2020
Brian J. F. Wong M.D.; Justus F. Ilgner M.D., Editor(s)

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