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Proceedings Paper

Estimation of spectroscopic attenuation coefficient in retinal nerve fiber layer for detection of glaucoma (Conference Presentation)
Author(s): Shuang Chang; Theodore Leng; Sylvia Groth; Audrey K. Bowden

Paper Abstract

In glaucoma, degeneration occurs in the retinal ganglion cells, whose cell bodies reside in the retinal nerve fiber layer (RNFL), leading to a decrease in the RNFL thickness. In clinical practice, optical coherence tomography (OCT) is used to measure the RNFL thickness for glaucoma diagnosis. Recent studies have shown that the degenerative process induces changes in optical properties of the RNFL, such as reflectivity. Because such properties can also be determined with OCT, we quantify this reduced scattering effect by determining spectroscopic attenuation coefficient (AC) in the RNFL with our proprietary autoConfoal algorithm, from two OCT B-scans of glaucomatous eyes.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340S (9 March 2020); doi: 10.1117/12.2546057
Show Author Affiliations
Shuang Chang, Vanderbilt Univ. (United States)
Theodore Leng, Stanford School of Medicine (United States)
Sylvia Groth, Vanderbilt Univ. Medical Ctr. (United States)
Audrey K. Bowden, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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