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Proceedings Paper

Intraoperative functional and metabolic brain mapping using hyperspectral imaging
Author(s): Charly Caredda; Laurent Mahieu-Williame; Raphaël Sablong; Michaël Sdika; Jacques Guyotat; Bruno Montcel
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Paper Abstract

The acquisition of narrow wavelength bands in the Near-Infrared (NIR) range using hyperspectral imaging have the potential to yield functional and metabolic information during a neurosurgical operation. The analysis of the reflectance spectra through the modified Beer-Lambert law and Monte Carlo simulations enable us to measure the concentration changes of oxy, deoxygenated hemoglobin and cytochrome-c-oxidase during the video acquisition. A functional model has been implemented to evaluate the functional brain areas following neuronal activation by physiological stimuli. The results show a good correlation between the computed quantitative functional maps and the brain areas identified by electrical brain stimulation. This work demonstrates that a quantitative modeling of the brain hemodynamic and metabolic biomarkers could evaluate in a robust way the functional areas and the cellular energy metabolism during neurosurgery.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11225, Clinical and Translational Neurophotonics 2020, 112250B (21 February 2020); doi: 10.1117/12.2545968
Show Author Affiliations
Charly Caredda, Univ. Claude Bernard Lyon 1 (France)
Laurent Mahieu-Williame, Univ. Claude Bernard Lyon 1 (France)
Raphaël Sablong, Univ. Claude Bernard Lyon 1 (France)
Michaël Sdika, Univ. Claude Bernard Lyon 1 (France)
Jacques Guyotat, Ctr. Hospitalier Univ. de Lyon (France)
Bruno Montcel, Univ. Claude Bernard Lyon 1 (France)

Published in SPIE Proceedings Vol. 11225:
Clinical and Translational Neurophotonics 2020
Steen J. Madsen; Victor X. D. Yang; Nitish V. Thakor, Editor(s)

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