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Proceedings Paper

Competitive binding of gold nanospheres and nanorods on DNA origami substrates
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Paper Abstract

DNA-directed assembly of gold nanoparticles into precise two- and three-dimensional patterns has enabled bold advances in probing their optical properties such as the local enhancement in their surface plasmon resonance. DNA nanostructures synthesized using the principles of DNA origami have been programmed to contain unique capture sites for positioning metal nanoparticles in diverse geometries for applications in biosensing, therapy, and miniature electronics. However, to enable scalability beyond simple 2-3 nanoparticle architectures, it is important to understand the requirement for orthogonal capture sequences for attaching more than a single gold nanoparticle on a DNA nanostructure. In this work, we sought to assemble an angular gold nanorod-nanosphere-nanorod pattern on a DNA origami triangle with multiple capture sites utilizing a common capture sequence. Results indicate that gold nanospheres preferentially bound to all the capture sites on the DNA origami triangle and prevented attachment of gold nanorods. This suggests that requirement for orthogonal capture sites is correlated with the physical properties of the individual nanoparticle such as shape and size.

Paper Details

Date Published: 21 February 2020
PDF: 5 pages
Proc. SPIE 11255, Colloidal Nanoparticles for Biomedical Applications XV, 1125509 (21 February 2020); doi: 10.1117/12.2545953
Show Author Affiliations
Divita Mathur, U.S. Naval Research Lab. (United States)
George Mason Univ. (United States)
William P. Klein, U.S. Naval Research Lab. (United States)
National Research Council (United States)
Hieu Bui, U.S. Naval Research Lab. (United States)
National Research Council (United States)
Eunkeu Oh, U.S. Naval Research Lab. (United States)
Jawad Naciri, U.S. Naval Research Lab. (United States)
Jake Fontana, U.S. Naval Research Lab. (United States)
Sebastián A. Díaz, U.S. Naval Research Lab. (United States)
Igor L. Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 11255:
Colloidal Nanoparticles for Biomedical Applications XV
Marek Osiński; Antonios G. Kanaras, Editor(s)

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