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Proceedings Paper

Optical coherence tomography for complex diagnosis of vulvar diseases
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Paper Abstract

Lichen Sclerosus is a chronic recurrent inflammatory dermatosis of unknown etiology, which affects both the skin and also the mucous membrane and is usually localized at the genital area. OCT angiography is a promising tool for microcirculation mapping in 3D with ~micrometer resolution. During the study, we developed and implemented a robust real time OCT angiography realization for routine clinical practice. This allows clinicians to combine structural OCT imaging with angiograms during routine clinical practice. Normal vulvar mucosa and dystrophic vulvar mucosa were analyzed by multimodal OCT. In the structural OCT scans of connective tissue, lymphatic vessels were visualized as contrast, low-signal regions. The angiographic images of the normal mucosa show dense, uniform network, mostly consisting of relatively thin vessels. Lymphatic vessel network presented by rare, very thick vessels. Further realization of OCT lymphangiography in real-time in parallel with OCT blood-vessel angiography can improve diagnostic capabilities of the multifunctional OCT in real clinical practice.

Paper Details

Date Published: 21 February 2020
PDF: 4 pages
Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122815 (21 February 2020); doi: 10.1117/12.2545801
Show Author Affiliations
Marina A. Sirotkina, Privolzhsky Research Medical Univ. (Russian Federation)
Arseniy L. Potapov, Privolzhsky Research Medical Univ. (Russian Federation)
Elizaveta A. Konovalova, Privolzhsky Research Medical Univ. (Russian Federation)
Nailya N. Vagapova, Nizhny Novgorod Regional Clinical Hospital (Russian Federation)
Ivan K. Safonov, Privolzhsky Research Medical Univ. (Russian Federation)
Anna A. Timakova, Sechenov Univ. (Russian Federation)
Stefka G. Radenska-Lopovok, Sechenov Univ. (Russian Federation)
Irina A. Kuznetsova, Privolzhsky Research Medical Univ. (Russian Federation)
Nizhny Novgorod Regional Clinical Hospital (Russian Federation)
Dmitry A. Karashtin, Institute of Applied Physics (Russian Federation)
Lev A. Matveev, Institute of Applied Physics (Russian Federation)
Alexander A. Moiseev, Institute of Applied Physics (Russian Federation)
Grigory V. Gelikonov, Institute of Applied Physics (Russian Federation)
Elena V. Zagaynova, Privolzhsky Research Medical Univ. (Russian Federation)
Natalia D. Gladkova, Privolzhsky Research Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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