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Proceedings Paper

Photosensitizing effect of Photolon using optical fiber probe to laser-irradiate thyroid cancer cells: oxidative stress-directed cell death
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Paper Abstract

In this study, Cylindrical Diffusing Optical Fiber Probe (CDOFP) is used for tumor treatment using Photolon-based photodynamic therapy induced apoptosis and necrosis in thyroid papillary carcinoma (BCPAP) cells. In conclusion, owing to multiple advantageous properties of Photolon as a PDT agent, including preferential accumulation in tumor, biodegradability and unprecedented photosensitizer packing, we evaluate Photolon mediated PDT as a minimally invasive, tumor specific treatment for thyroid cancer. the Photolon-PDT inhibited the growth of human papilloma thyroid cancer cells and effectively decreased xenograft tumor progression in both 10mm and 15mm diffusing length probe. Therefore, this study preliminarily suggests the use of CDOFP and Photolon-PDT for more effective treatment of human thyroid cancer.

Paper Details

Date Published: 20 February 2020
PDF: 9 pages
Proc. SPIE 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX, 112330L (20 February 2020);
Show Author Affiliations
GaYe Park, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
Yun-Hee Rhee, Laser Translational Clinical Trial Ctr. (Korea, Republic of)
HyeYeon Lee, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
Junho Lee, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
Hyunjoo Kim, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
ChangHyun Jung, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
Jaesun Kim, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
ChiHwan Ouh, Taihan Fiberoptics Co., Ltd. (Korea, Republic of)
Phil-Sang Chung, Laser Translational Clinical Trial Ctr. (Korea, Republic of)


Published in SPIE Proceedings Vol. 11233:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX
Israel Gannot, Editor(s)

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