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Proceedings Paper

Brain metabolism changes in cases of impaired breathing or blood circulation in rodents evaluated by real time optical spectroscopy methods
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Paper Abstract

The aim of the study was to compare the metabolic activity of brain cortex after the acute hypoxia caused by the impairment of breathing or blood circulation. Male Wistar rats were randomized in two groups: impaired breathing and blood circulation failure groups. Fluorescence under 365 and 450 nm excitation and diffuse reflectance intensity at 550-820 nm range were estimated. We found that after long-term hypoxic conditions, notable metabolic changes occur. We suppose that oxygen deficiency causes an activation of the GABA shunt mechanism. In cases of blood circulation failure, fluorescence intensity changes faster than in cases of breathing impairment.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341E (21 February 2020); doi: 10.1117/12.2545708
Show Author Affiliations
Gennadii A. Piavchenko, I.M. Sechenov First Moscow State Medical Univ. (Russian Federation)
Orel State Univ. named after I. S. Turgenev (Russian Federation)
Evgeniya S. Seryogina, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Ksenia Yu. Kandurova, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Valery V. Shupletsov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Igor O. Kozlov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Dmitry D. Stavtsev, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Olga A. Stelmashchuk, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Evgeny A. Zherebtsov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Univ. of Oulu (Finland)
Viktor V. Dremin, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Univ. of Oulu (Finland)
Aleksander G. Alekseyev M.D., Orel State Univ. named after I.S. Turgenev (Russian Federation)
Sergey L. Kuznetsov M.D., I.M. Sechenov First Moscow State Medical Univ. (Russian Federation)
Andrey V. Dunaev, Orel State Univ. named after I. S. Turgenev (Russian Federation)
Igor V. Meglinski, Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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