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Proceedings Paper

Multimodal optical coherence tomography for quantitative diagnosis of breast cancer subtypes
Author(s): Ekaterina V. Gubarkova; Alexander A. Sovetsky; Vladimir Y. Zaitsev; Dmitriy A. Vorontsov; Lev A. Matveev; Alexander L. Matveyev; Alexander A. Moiseev; Sergey S. Kuznetsov; Marina A. Sirotkina; Alexey Yu. Vorontsov; Gregory V. Gelikonov; Elena V. Zagaynova; Natalia D. Gladkova
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Paper Abstract

A multimodal optical coherence tomography (MM OCT) combining microstructural cross-polarization (CP) imaging and compression OCT-elastography (OCE) was employed in this study. The research was carried out on the noninvasive and invasive subtypes of human breast cancer. This study demonstrates how CP OCT combined with OCTelastography identifies an example of DCIS cancer that progresses into invasive breast cancer. OCE images more clearly show the cross sections of the ducts filled with tumor cells for DCIS (high-contrast structures with clear boundaries and high stiffness values) surrounded by areas with lower stiffness corresponding to fibrous stroma regions. The regions of invasive breast cancer in OCE-scans look as zones with strongly increased stiffness, which well agrees with the histology. Percentage of pixels with different characteristic stiffness ("stiffness spectrum") in the OCTelastography images was assessed to quantitatively visualize stiffness of tumor. The demonstrated ability of MM OCT imaging for breast cancer subtypes differentiation and breast cancer margin assessment is important for improved managements of patients.

Paper Details

Date Published: 21 February 2020
PDF: 4 pages
Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112282F (21 February 2020); doi: 10.1117/12.2545695
Show Author Affiliations
Ekaterina V. Gubarkova, Privolzhsky Research Medical Univ. (Russian Federation)
Alexander A. Sovetsky, Institute of Applied Physics (Russian Federation)
Vladimir Y. Zaitsev, Institute of Applied Physics (Russian Federation)
Dmitriy A. Vorontsov, Nizhny Novgorod Regional Oncology Hospital (Russian Federation)
Lev A. Matveev, Institute of Applied Physics (Russian Federation)
Alexander L. Matveyev, Institute of Applied Physics (Russian Federation)
Alexander A. Moiseev, Institute of Applied Physics (Russian Federation)
Sergey S. Kuznetsov, Privolzhsky Research Medical Univ. (Russian Federation)
Marina A. Sirotkina, Privolzhsky Research Medical Univ. (Russian Federation)
Alexey Yu. Vorontsov, Nizhny Novgorod Regional Oncology Hospital (Russian Federation)
Gregory V. Gelikonov, Institute of Applied Physics (Russian Federation)
Elena V. Zagaynova, Privolzhsky Research Medical Univ. (Russian Federation)
Natalia D. Gladkova, Privolzhsky Research Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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