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Proceedings Paper

Nanoplasmonic imaging biosensor for digital detection of disease biomarkers (Conference Presentation)

Paper Abstract

We present a nanoparticle (NP) enhanced imaging-based plasmonic biosensing technique using gold nanohole arrays (Au-NHAs) that enables highly sensitive protein detection with single analyte resolution in a one-step sandwich immunoassay. By digital quantification of individual Au-NP bound molecules on large area plasmonic surface, the portable biosensor enables rapid and robust detection of disease biomarkers from patient serum in hospital settings. Using mass-scalable deep-UV lithography (DUVL) sensor fabrication and simple LED based imaging set-up in a microarray format, our novel technology provides a powerful tool for clinical biomarker detection in a highly multiplexed manner.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 1125406 (10 March 2020); doi: 10.1117/12.2545619
Show Author Affiliations
Alexander Belushkin, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Filiz Yesilkoy, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Hatice Altug, Ecole Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 11254:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII
Dror Fixler; Ewa M. Goldys, Editor(s)

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