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Proceedings Paper

Multiphoton and confocal imaging of precisely cut oral cancer tumor sections for personalized medicine
Author(s): Shu-Jen Chiang; Po-Hang Tseng; Hsu-Cheng Huang; Shih-Chi Chen; Shean-Jen Chen; Mei-Chun Lin; Pei-Jen Lou M.D.; Chen-Yuan Dong
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Paper Abstract

Traditionally, testing of therapeutic agents uses two-dimensional cell cultures which does not recapitulate the complex, three-dimensional architecture of tissues. In the case of cancer drug development, immunotherapy (IT) emerged as an effective treatment strategy for the patients who respond to therapy. However, the overall patient response rate for immunotherapy is around 25%. Therefore, there is a need to develop more effective drug testing platform for cancer patients. In this work, we develop three-dimensional tissue cultures of human oral cancer slices. We observed the growth dynamics of the tissue sections for up to 28 days. Their viability over extended periods suggest that the tissue sections may be used for personalized drug testing.

Paper Details

Date Published: 21 February 2020
PDF: 5 pages
Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 1124427 (21 February 2020); doi: 10.1117/12.2545617
Show Author Affiliations
Shu-Jen Chiang, National Taiwan Univ. (Taiwan)
Po-Hang Tseng, National Taiwan Univ. (Taiwan)
Hsu-Cheng Huang, National Taiwan Univ. (Taiwan)
Shih-Chi Chen, The Chinese Univ. of Hong Kong (Hong Kong, China)
Shean-Jen Chen, National Chiao Tung Univ. (Taiwan)
Mei-Chun Lin, National Taiwan Univ. Hospital (Taiwan)
Pei-Jen Lou M.D., National Taiwan Univ. Hospital (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)


Published in SPIE Proceedings Vol. 11244:
Multiphoton Microscopy in the Biomedical Sciences XX
Ammasi Periasamy; Peter T. C. So; Karsten König, Editor(s)

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