Share Email Print
cover

Proceedings Paper

Photoacoustic microscopy by spatial overlap modulation using femtosecond optical pulse train (Conference Presentation)

Paper Abstract

Two-photon photoacoustic microscopy (TP-PAM) can visualize deep structures in living tissues with high spatial resolution determined by the volume of nonlinear absorption. Generally, the out-of-focus background fluorescence limits the imaging depth in nonlinear optical microscopies. In this study, to overcome this drawback that is also expected to exist in TP-PAM, we propose TP-PAM with spatial overlap modulation using femtosecond optical pulse train. Because the modulation depth of the spatial overlap in the focal region is much greater than those in out-of-focus regions, the out-of-focus background is effectively rejected by extracting the modulated photoacoustic signals.

Paper Details

Date Published: 6 March 2020
PDF
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124022 (6 March 2020); doi: 10.1117/12.2545607
Show Author Affiliations
Yoshihisa Yamaoka, Saga Univ. (Japan)
Koki Matsumoto, Saga Univ. (Japan)
Yusuke Notsuka, Saga Univ. (Japan)
Eiji Takahashi, Saga Univ. (Japan)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray