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Proceedings Paper

Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions
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Paper Abstract

Cardiovascular complication is a major health concern for diabetic patients. Elevated blood sugar levels lead to the formation of advanced glycation end products (AGEs), which are implicated in diabetic pathogenesis. In this study, we investigate the effect of prolonged exposure to elevated sugar level by studying the combined effect of diffusion and glycation rate in arteries from different commonly-consumed simple sugars. Since some AGEs are autofluorescent, we will perform multiphoton autofluorescence imaging to quantify the rates of fluorescent AGEs formation in elastic fibers and collagen fibers. Cross-section imaging of arteries and spatial and temporal profiles of autofluorescence of the blood vessel will be investigated.

Paper Details

Date Published: 25 February 2020
PDF: 5 pages
Proc. SPIE 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020, 112150D (25 February 2020); doi: 10.1117/12.2545589
Show Author Affiliations
Chih-Ju Lin, National Taiwan Univ. (Taiwan)
Jeon Woong Kang, Laser Biomedical Research Ctr. (United States)
Peter T. C. So, Laser Biomedical Research Ctr. (United States)
Massachusetts Institute of Technology (United States)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 11215:
Diagnostic and Therapeutic Applications of Light in Cardiology 2020
Kenton W. Gregory M.D.; Laura Marcu, Editor(s)

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