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Proceedings Paper

Classifying diffuse reflectance spectroscopy measurements of locations with mixed tissue types and DCIS (Conference Presentation)

Paper Abstract

Diffuse Reflectance Spectroscopy (DRS) measurements can discriminate pure fat tissue from pure invasive carcinoma. Here we investigate 1) the difference between DRS measurements of invasive carcinoma and ductal carcinoma in situ (DCIS), and 2) the classification accuracy of DRS measurements of a mixture of tissue types. DRS measurements (850–1600nm) were acquired from 107 slices (n = 1493 locations) of breast specimens. There were no significant differences between the DRS spectra of invasive carcinoma or DCIS. All locations with >75% malignant tissue were correctly classified, including DCIS locations. With a decreasing percentage of malignant tissue, the classification accuracy decreased.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340T (9 March 2020); doi: 10.1117/12.2545569
Show Author Affiliations
Lisanne L. de Boer, The Netherlands Cancer Institute (Netherlands)
Esther Kho, The Netherlands Cancer Institute (Netherlands)
Marie-Jeanne T. F. D. Vrancken Peeters, The Netherlands Cancer Institute (Netherlands)
Frederieke van Duijnhoven, The Netherlands Cancer Institute (Netherlands)
Koen K. Van de Vijver, The Netherlands Cancer Institute (Netherlands)
Univ. Ziekenhuis Gent (Belgium)
Joyce Sanders, The Netherlands Cancer Institute (Netherlands)
Benno H. W. Hendriks, Technische Univ. Delft (Netherlands)
Philips Research (Netherlands)
Henricus J. C. M. Sterenborg, The Netherlands Cancer Institute (Netherlands)
Amsterdam UMC (Netherlands)
Theo J. M. Ruers, The Netherlands Cancer Institute (Netherlands)
Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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