Share Email Print
cover

Proceedings Paper

pH-sensitive shortwave infrared quantum dots for In vivo pH mapping (Conference Presentation)
Author(s): Manon Debayle; Xiangzhen Xu; Nicolas Lequeux; Thomas Pons

Paper Abstract

Shortwave infrared quantum dots (QDs) are promising probes for in vivo imaging in depth. Here, we present two strategies to design pH-sensitive ratiometric QD in vivo probes. In the first one, central fluorescent QDs are coated with a copolymer ligand and conjugated to gold nanoparticle (AuNP) quenchers. As the pH decreases from physiological (7.5) to slightly acidic (5.5−6), the copolymer reversibly shrinks, which modulates the QD fluorescence signal through energy transfer. In a second design, QDs and AuNPs are encapsulated into micelles using pH-sensitive copolymer surfactants, providing stability in serum, sharp pH transitions and high contrast.

Paper Details

Date Published: 10 March 2020
PDF
Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 1125607 (10 March 2020); doi: 10.1117/12.2545563
Show Author Affiliations
Manon Debayle, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (France)
Xiangzhen Xu, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (France)
Nicolas Lequeux, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (France)
Thomas Pons, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (France)


Published in SPIE Proceedings Vol. 11256:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray