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Proceedings Paper

Rapid switching between various wavelength regions for coherent Raman imaging with a robust all-fiber source (Conference Presentation)
Author(s): Tim Hellwig; Maximilian Brinkmann; Carsten Fallnich

Paper Abstract

We present coherent anti-Stokes Raman (CARS) imaging with our robust all-fiber optical parametric oscillator (FOPO) that is tunable across the whole bio-relevant spectral region (700 to 3530 wavenumbers) in less than 5 ms. The all-fiber operation allows to operate the FOPO on a regular laboratory cart, maximize temporal pulse overlap by dispersion management and inherently minimize beam-pointing. We present first CARS images of DMSO-d6 infiltration into mouse skin imaged in the silent as well as CH-stretch region without any alignment other than electronically tuning the wavelength. The FOPO is ideally suited for label-free, hyperspectral imaging, e.g., in translational research.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 1125118 (10 March 2020); doi: 10.1117/12.2545491
Show Author Affiliations
Tim Hellwig, Westfälische Wilhelms-Univ. Münster (Germany)
Refined Laser Systems UG (Germany)
Maximilian Brinkmann, Westfälische Wilhelms-Univ. Münster (Germany)
Refined Laser Systems UG (Germany)
Carsten Fallnich, Westfälische Wilhelms-Univ. Münster (Germany)
Cells-in-Motion Cluster of Excellence (Germany)

Published in SPIE Proceedings Vol. 11251:
Label-free Biomedical Imaging and Sensing (LBIS) 2020
Natan T. Shaked; Oliver Hayden, Editor(s)

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