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Proceedings Paper

Red blood cell membranes-camouflaged gold nanostars for enhanced photoacoustic diagnosis and photothermal treatment of liver cancer (Conference Presentation)
Author(s): Xiazi Huang; Puxiang Lai

Paper Abstract

A biomimetic photoacoustic nano-probe is synthesized for enhanced the diagnostic accuracy of hepatocellular carcinoma. It is prepared by using erythrocyte membrane to coat the gold nano-star which shows significant photothermal effect. This probe can escape the clearance by mononuclear phagocytic system because of the inherent proteins on the surface of the erythrocyte membrane. Such an ability to evade immune clearance allows a longer circulation time in vivo, promotes probe enrichment at tumor site, and improves signal-to-noise ratio. Sequentially, it is used as an agent of non-invasive photothermal treatment for tumor and experimentally perform a longer life span of mice.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560D (10 March 2020); doi: 10.1117/12.2545469
Show Author Affiliations
Xiazi Huang, The Hong Kong Polytechnic Univ. (Hong Kong, China)
Puxiang Lai, The Hong Kong Polytechnic Univ. (Hong Kong, China)


Published in SPIE Proceedings Vol. 11256:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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