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Proceedings Paper

In vivo imaging of shock wave-induced nitric oxide generation in the rat cortex (Conference Presentation)

Paper Abstract

We hypothesized that generation of nitric oxide (NO) was associated with persistent hemodynamic abnormalities observed in the rat cortex exposed to a shock wave. To examine this speculation, we performed in vivo imaging of NO in the rat cortex exposed to a laser-induced shock wave (LISW). An NO sensitive fluoroprobe (DAF-2 DA) was applied to the cortical surface, and NO-originating fluorescence was observed under the stereoscopic fluorescence microscope. We observed that the fluorescence intensity in perivascular spaces as well as in parenchyma was drastically increased after LISW application. Intense fluorescence spots in the parenchyma probably indicate NO generation from neurons.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11225, Clinical and Translational Neurophotonics 2020, 1122504 (9 March 2020); doi: 10.1117/12.2545452
Show Author Affiliations
Masaki Inaba, Tokyo Univ. of Agriculture and Technology (Japan)
Satoko Kawauchi, National Defense Medical College (Japan)
Takeshi Adachi, National Defense Medical College (Japan)
Shunichi Sato, National Defense Medical College (Japan)
Izumi Nishidate, Tokyo Univ. of Agriculture and Technology (Japan)


Published in SPIE Proceedings Vol. 11225:
Clinical and Translational Neurophotonics 2020
Steen J. Madsen; Victor X. D. Yang; Nitish V. Thakor, Editor(s)

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