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Proceedings Paper

A backside-illuminated low-noise multispectral imager for near-infrared fluorescence image-guided surgery (Conference Presentation)
Author(s): Steven M. Blair; Amit Deliwala; Eric Chen; Sailesh Subashbabu; Anthony Li; Mebin George; Missael Garcia; Nan Cui; Viktor Gruev

Paper Abstract

Near-infrared fluorescence image-guided surgery offers substantial benefits for both surgeons and patients, but high-performance near-infrared fluorescent molecular markers are not available for clinical application. To enable adoption of a wider variety of fluorescent markers, we have developed a single-chip snapshot multispectral imaging system that combines a scientific CMOS image sensor with high quantum efficiency (94%), low read noise (1.6 e-), and high dynamic range (91 dB) and pixelated interference filters that enable color/near-infrared imaging without co-registration error The fully integrated imaging system is currently being evaluated for tumor detection with targeted probes and sentinel lymph node detection with indocyanine green.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220A (10 March 2020); doi: 10.1117/12.2545389
Show Author Affiliations
Steven M. Blair, Univ. of Illinois (United States)
Amit Deliwala, Univ. of Illinois (United States)
Eric Chen, Univ. of Illinois (United States)
Sailesh Subashbabu, Univ. of Illinois (United States)
Anthony Li, Univ. of Illinois (United States)
Mebin George, Univ. of Illinois (United States)
Missael Garcia, Univ. of Illinois (United States)
Nan Cui, Washington Univ. in St. Louis (United States)
Viktor Gruev, Univ. of Illinois (United States)

Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)

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