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Proceedings Paper

Multifrequency-swept optical coherence microscopy for full-field in-vivo intracochlear vibration measurement
Author(s): Samuel Choi; Fumiaki Nin; Takeru Ota; Hiroshi Hibino
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Paper Abstract

The sensory epithelium in the cochlea of the inner ear transduces sound energy into electrical signals, which are essential for a neurotransmitter release. Nevertheless, the in vivo behavior and correlation of the dynamics among each layer remains unclear. To assess the wide-range motion within a living organism, we develop multifrequency-swept optical coherence microscopic vibrometry (MS-OCMV). This method employed the wide-filed heterodyne interferometric vibration measurement technique, which can capture the full-field vibration amplitude and phase distributions with optical coherence microscopy (OCM). In this system, we newly introduced the broadband multifrequency supercontinuum (SC) as a light source. Manipulating the frequency interval of the multifrequency SC can determine the depth of the region of interest where the two-dimensional biological vibration distributed as well as to conduct 3D tomographic volumetric imaging. In this manuscript, we demonstrate the accuracy of two-dimensional surface vibration measurement and the underlying performance of 3D tomographic imaging. We report the measurement results of vibrational motions induced by sound stimuli on the sensory epithelium of a living guinea pig using MS-OCMV.

Paper Details

Date Published: 21 February 2020
PDF: 9 pages
Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112281Q (21 February 2020); doi: 10.1117/12.2545362
Show Author Affiliations
Samuel Choi, Niigata Univ. (Japan)
Japan Agency for Medical Research and Development (Japan)
Fumiaki Nin, Niigata Univ. (Japan)
Japan Agency for Medical Research and Development (Japan)
Takeru Ota, Niigata Univ. (Japan)
Japan Agency for Medical Research and Development (Japan)
Hiroshi Hibino, Niigata Univ. (Japan)
Japan Agency for Medical Research and Development (Japan)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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