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Proceedings Paper

Vaccine visualization using a zwitterionic near-infrared fluorophore (Conference Presentation)

Paper Abstract

There remains a paucity of methodological tools to determine the biodistribution of vaccine antigens. In response to this, we established a near-infrared (NIR) imaging method using a NIR fluorophore, ZW800-1C, conjugated with different sizes of vaccine antigens that allows for real-time monitoring of the fate of delivered vaccines in vivo. The fluorescent signal observed using the system after a model vaccine injection in mice recapitulated the size-dependent transport of the vaccine into the secondary lymphoid tissue. This methodology can be broadly applied for optimization of formulations and safety evaluation of clinical vaccines.

Paper Details

Date Published: 20 April 2020
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Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 1121906 (20 April 2020); doi: 10.1117/12.2545297
Show Author Affiliations
Wataru Katagiri, Gordon Ctr. for Medical Imaging (United States)
Keio Univ. (Japan)
Marc-André Tetrault, Gordon Ctr. for Medical Imaging (United States)
Homan Kang, Gordon Ctr. for Medical Imaging (United States)
Sinyoung Jeong, Wellman Ctr. for Photomedicine (United States)
Conor L. Evans, Wellman Ctr. for Photomedicine (United States)
Hak Soo Choi, Gordon Ctr. for Medical Imaging (United States)
Satoshi Kashiwagi, Gordon Ctr. for Medical Imaging (United States)


Published in SPIE Proceedings Vol. 11219:
Visualizing and Quantifying Drug Distribution in Tissue IV
Kin Foong Chan; Conor L. Evans, Editor(s)

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