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Proceedings Paper

Photodynamic inactivation using curcumin-loaded Pluronic® F-127 over Streptococcus mutans biofilm (Conference Presentation)
Author(s): Alessandra Nara de Souza Rastelli; Diego Dantas Lopes dos Santos; João Felipe Bessegato; Joao Augusto Oshiro Jr.; Marlus Chorilli; Vanderlei S. Bagnato

Paper Abstract

Photodynamic inactivation (PDI) is described as a promising therapy for oral inactivation. Due to the low aqueous solubility of curcumin, appropriate delivery systems are required to facilitate its use as a photosensitizer. This study evaluated the effectiveness of on Streptococcus mutans biofilm using curcumin-loaded Pluronic® 127. The micelles were characterized by different techniques. MIC and MBC were determined, and after that the cell viability of the biofilm irradiated by blue LED was obtained by CFU/mL and by confocal microscopy. Curcumin-loaded Pluronic® F-127 micelles can be a viable alternative for curcumin to improve the water solubility and the antimicrobial photodynamic effect.

Paper Details

Date Published: 10 March 2020
PDF
Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230J (10 March 2020); doi: 10.1117/12.2545296
Show Author Affiliations
Alessandra Nara de Souza Rastelli, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Diego Dantas Lopes dos Santos, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
João Felipe Bessegato, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Joao Augusto Oshiro Jr., Univ. Estadual Paulista "Julio de Mesquita Filho" (Brazil)
Marlus Chorilli, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Vanderlei S. Bagnato, Univ. de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

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