Photodynamic inactivation (PDI) is described as a promising therapy for oral inactivation. Due to the low aqueous solubility of curcumin, appropriate delivery systems are required to facilitate its use as a photosensitizer. This study evaluated the effectiveness of on Streptococcus mutans biofilm using curcumin-loaded Pluronic® 127. The micelles were characterized by different techniques. MIC and MBC were determined, and after that the cell viability of the biofilm irradiated by blue LED was obtained by CFU/mL and by confocal microscopy. Curcumin-loaded Pluronic® F-127 micelles can be a viable alternative for curcumin to improve the water solubility and the antimicrobial photodynamic effect.

Date Published: 10 March 2020
PDF
Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230J (10 March 2020); doi: 10.1117/12.2545296

Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)