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Proceedings Paper

Optical evaluation of microvascular function at early and chronic stages of diabetes
Author(s): Shotaro Sasaki; Mikie Nakabayashi; Yumie Ono; Masashi Ichinose
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Paper Abstract

We investigated blood flow response for reactive hyperemia test in type1 diabetic and control rats using diffuse correlation spectroscopy (DCS). The baseline blood flow, peak amplitude and time to peak blood flow responses after releasing from ischemia were significantly decreased after induction of hyperglycemic state in diabetic rats. Furthermore, the baseline blood flow and the peak amplitude were significantly decreased from 1st week to 10th week in diabetic rats, suggesting the progress of vascular dysfunction caused by sustained glycemic stress. This research showed a potential of DCS to diagnose vascular function in diabetes that was altered by acute and chronic hyperglycemic stress.

Paper Details

Date Published: 21 February 2020
PDF: 5 pages
Proc. SPIE 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables, 112370R (21 February 2020); doi: 10.1117/12.2545267
Show Author Affiliations
Shotaro Sasaki, Meiji Univ. (Japan)
Mikie Nakabayashi, Meiji Univ. (Japan)
Yumie Ono, Meiji Univ. (Japan)
Masashi Ichinose, Meiji Univ. (Japan)


Published in SPIE Proceedings Vol. 11237:
Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables
Babak Shadgan; Amir H. Gandjbakhche, Editor(s)

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