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Proceedings Paper

All-optical reflection-mode microscopic histology of unstained human tissues (Conference Presentation)

Paper Abstract

Surgery remains the primary method of care for multiple types of solid cancer. The goal of surgical oncology is to remove all tumorous tissue from the body. Frozen sectioning is commonly used during surgery to assess margin status. However, this method can be unreliable as the slides can be difficult to interpret. Using a recently reported imaging modality, Photoacoustic Remote Sensing (PARS), we present the first in human non-contact histology-like imaging in reflection mode. Cellular morphology alongside blood vessels are imaged in the human breast, gastrointestinal, and skin tissues. These images then compared with conventional hematoxylin and eosin-stained samples.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124009 (6 March 2020); doi: 10.1117/12.2545260
Show Author Affiliations
Saad Rasheed Abbasi, Univ. of Waterloo (Canada)
Martin Le, Univ. of Waterloo (Canada)
Serene Abu-Sardanah, Univ. of Waterloo (Canada)
Benjamin Ecclestone, Univ. of Waterloo (Canada)
Kevan Bell, illumiSonics Inc. (Canada)
Deepak Dinakaran, illumiSonics Inc. (Canada)
Gilbert Bigras, Univ. of Alberta (Canada)
John R. Mackey, illumiSonics Inc. (Canada)
Parsin H. Reza, Univ. of Waterloo (Canada)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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