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Proceedings Paper

Fluorescence lifetime-based tumor contrast enhancement using targeted near infrared probes (Conference Presentation)

Paper Abstract

Imaging techniques for highly specific detection of cancer cells in-vivo can have applications ranging from preclinical drug discovery studies to clinical cancer diagnosis and surgical therapy. While fluorescence imaging using cancer-targeted antibodies has shown promise, non-specific probe accumulation in tissue results in a significant background fluorescence, reducing detection sensitivity using traditional intensity-based continuous wave (CW) fluorescence imaging. Here we demonstrate that fluorescence lifetime imaging can provide significant tumor contrast enhancement over CW intensity, with the use of Indocyanine Green and anti-epidermal growth factor receptor (EGFR) antibody conjugated to the fluorescent dye IRDye800CW.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220G (10 March 2020); doi: 10.1117/12.2545246
Show Author Affiliations
Rahul Pal, Massachusetts General Hospital (United States)
Anand T. Kumar, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)

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