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Proceedings Paper

Artificial repeat proteins evolved as habit modifiers and protein origami templates for the morphosynthesis of (111)-terminated gold nanocrystals (Conference Presentation)

Paper Abstract

Artificial proteins are created that offer a universal and biocompatible approach to control the morphology of metal nanocrystals. First, we select, from a large library of artificial proteins (alpha-Repins), individuals that show specific binding for Au(111) facets. Gold nanocrystals synthesized with such -Rep are exclusively terminated by Au(111) planes. The protein-coated nanocrystals are then functionalized to perform biomolecule-driven self-assembly and on-surface enzymatic catalysis. Alternatively, growth templates with a complex and rigid shape could be constructed from two artificial proteins selected to act as the supercoil unit and the staple that spontaneously self-assemble into helical nanotubular templates observed by cryo-electron microscopy.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11255, Colloidal Nanoparticles for Biomedical Applications XV, 112550B (10 March 2020); doi: 10.1117/12.2545239
Show Author Affiliations
Janak Prasad, Ctr. d'Elaboration de Matériaux et d'Etudes Structurales, CNRS (France)
Sébastien Viollet, Institut de biologie intégrative de la cellule, Univ. Paris-Sud (France)
CEA (France)
Laureen Moreaud, Ctr. d'Elaboration de Matériaux et d'Etudes Structurales, CNRS (France)
Agathe Urvoas, Institut de Biologie Integrative de la Cellule (France)
Marie Valerio-Lepiniec, Institut de Biologie Integrative de la Cellule (France)
Agnès Mesneau, Institut de Biologie Integrative de la Cellule (France)
Philippe Minard, Institut de Biologie Integrative de la Cellule (France)
Erik Dujardin, Ctr. d'Elaboration de Matériaux et d'Etudes Structurales, CNRS (France)


Published in SPIE Proceedings Vol. 11255:
Colloidal Nanoparticles for Biomedical Applications XV
Marek Osiński; Antonios G. Kanaras, Editor(s)

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