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Proceedings Paper

Astrocyte sensitivity to pulsed infrared light: molecular, physiological, and mechanistic insights (Conference Presentation)
Author(s): Wilson R. Adams; Ana I. Borrachero-Conejo; Emanuela Saracino; Manqing Wang; Tamara Posati; Graham A. Throckmorton; John Logan Jenkins; Jeremy B. Ford; Roberto Zamboni; Marco Caprini; Grazia Paola Nicchia; E. Duco Jansen; Valentina Benfenati; Anita Mahadevan-Jansen

Paper Abstract

We have shown previously that astrocytes are independently sensitive to IR exposure in the context of infrared neural stimulation (INS). More recently, our advances have identified some physiological basis of astrocytic sensitivity to INS. Single pulse INS evokes intracellular calcium signaling primarily mediated through inositol-triphosphate receptor (IP¬3R) activation, rather than thermally sensitive transient receptor protein (TRP) pathways. Interestingly, different dosing strategies for IR appear to evoke different physiology. Our findings suggest that tailoring irradiation parameters with INS may be used for preferentially drive separate physiological responses in astrocytes, and possibly other cell types.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270N (9 March 2020); doi: 10.1117/12.2545237
Show Author Affiliations
Wilson R. Adams, Vanderbilt Univ. (United States)
Ana I. Borrachero-Conejo, Vanderbilt Univ. (United States)
Emanuela Saracino, Istituto per la Sintesi Organica e la Fotoreattività (Italy)
Manqing Wang, Chongqing Univ. (China)
Tamara Posati, Istituto per lo Studio dei Materiali Nanostrutturati (Italy)
Graham A. Throckmorton, Vanderbilt Univ. (United States)
John Logan Jenkins, Vanderbilt Univ. (United States)
Jeremy B. Ford, Vanderbilt Univ. (United States)
Roberto Zamboni, Istituto per la Sintesi Organica e la Fotoreattività (Italy)
Marco Caprini, Univ. degli Studi di Bologna (Italy)
Grazia Paola Nicchia, Univ. degli Studi di Bari Aldo Moro (Italy)
E. Duco Jansen, Vanderbilt Univ. (United States)
Valentina Benfenati, Istituto per la Sintesi Organica e la Fotoreattività (Italy)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 11227:
Optogenetics and Optical Manipulation 2020
Samarendra K. Mohanty; E. Duco Jansen; Anna W. Roe, Editor(s)

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