
Proceedings Paper
Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)
Paper Abstract
Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.
Paper Details
Date Published: 10 March 2020
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Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 1122204 (10 March 2020); doi: 10.1117/12.2545222
Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)
Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 1122204 (10 March 2020); doi: 10.1117/12.2545222
Show Author Affiliations
Fabio Feroldi, Vrije Univ. Amsterdam (Netherlands)
Margherita Vaselli, Vrije Univ. Amsterdam (Netherlands)
Mariska Verlaan, Amsterdam UMC (Netherlands)
Helene Knaus, Vrije Univ. Amsterdam (Netherlands)
Valentina Davidoiu, Vrije Univ. Amsterdam (Netherlands)
Margherita Vaselli, Vrije Univ. Amsterdam (Netherlands)
Mariska Verlaan, Amsterdam UMC (Netherlands)
Helene Knaus, Vrije Univ. Amsterdam (Netherlands)
Valentina Davidoiu, Vrije Univ. Amsterdam (Netherlands)
Danielle Vugts, Amsterdam UMC (Netherlands)
Carla Molthoff, Amsterdam UMC (Netherlands)
Guus van Dongen, Amsterdam UMC (Netherlands)
Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)
Carla Molthoff, Amsterdam UMC (Netherlands)
Guus van Dongen, Amsterdam UMC (Netherlands)
Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)
Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)
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