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Proceedings Paper

Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)
Author(s): Fabio Feroldi; Margherita Vaselli; Mariska Verlaan; Helene Knaus; Valentina Davidoiu; Danielle Vugts; Carla Molthoff; Guus van Dongen; Johannes F. de Boer

Paper Abstract

Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 1122204 (10 March 2020); doi: 10.1117/12.2545222
Show Author Affiliations
Fabio Feroldi, Vrije Univ. Amsterdam (Netherlands)
Margherita Vaselli, Vrije Univ. Amsterdam (Netherlands)
Mariska Verlaan, Amsterdam UMC (Netherlands)
Helene Knaus, Vrije Univ. Amsterdam (Netherlands)
Valentina Davidoiu, Vrije Univ. Amsterdam (Netherlands)
Danielle Vugts, Amsterdam UMC (Netherlands)
Carla Molthoff, Amsterdam UMC (Netherlands)
Guus van Dongen, Amsterdam UMC (Netherlands)
Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)

Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)

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