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Proceedings Paper

Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)
Author(s): Joel W. Y. Tan; Jeff Folz; Raoul Kopelman; Xueding Wang

Paper Abstract

Recently, Eil et al. showed that tumors with necrotic cores had elevated K+ concentrations due to the release of K+ by necrosis, which acts to suppress T-cell function by high extracellular K+ concentration. These findings demonstrate the importance of developing a tool for imaging K+ distributions. Here, we demonstrate K+ nanosensor-enabled photoacoustic imaging for measuring K+ levels in vivo. The nanosensor is an in-house synthesized optical contrast agent that is sensitive to K+ levels within biological ranges. The use of this K+ nanosensor, combined with multi-spectral photoacoustic imaging, allowed measurement of K+ levels in vivo.

Paper Details

Date Published: 20 April 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402B (20 April 2020); doi: 10.1117/12.2545205
Show Author Affiliations
Joel W. Y. Tan, Univ. of Michigan (United States)
Jeff Folz, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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