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Proceedings Paper

Adaptive optics line-scan OCT for high-speed imaging of retinal structure and function (Conference Presentation)

Paper Abstract

We developed a high-speed adaptive optics, line-scan spectral domain OCT and used it to characterize stimulus-induced optical path length changes in cones with high spatiotemporal resolution. We find that individual cone outer segments exhibit a biphasic light-induced response—a rapid axial shrinkage followed by a gradual increase in optical path length, both increasing in magnitude with the stimulus intensity. AO line-scan OCT thus offers high-speed volume acquisitions, high phase stability, sub-ms temporal resolution and cellular-scale spatial resolution, that together enable imaging retinal structure and function in health and disease.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121812 (9 March 2020); doi: 10.1117/12.2545204
Show Author Affiliations
Vimal Prabhu Pandiyan, Univ. of Washington (United States)
Aiden M. Bertelli, Univ. of Washington (United States)
James Kuchenbecker, Univ. of Washington (United States)
Kevin C. Boyle, Stanford Univ. (United States)
Tong Ling, Stanford Univ. (United States)
B. Hyle Park, Univ. of California, Riverside (United States)
Daniel Palanker, Stanford Univ. (United States)
Austin Roorda, Univ. of California, Berkeley (United States)
Ramkumar Sabesan, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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