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Proceedings Paper

Phase dual-slopes for enhanced depth sensitivity in diffuse optical imaging (Conference Presentation)

Paper Abstract

We introduce a novel method to enhance the sensitivity of near-infrared spectroscopy (NIRS) to deep tissue (i.e. brain cortex, skeletal muscle, etc.) in non-invasive diffuse optical measurements. Our method relies on the collection of the phase of photon-density waves, launched by intensity-modulated light in frequency-domain NIRS, from two paired sets of multi-distance data. The two sets of data are combined into a phase dual-slope, which features a stronger sensitivity to deeper vs. superficial tissue. For typical conditions of functional NIRS, the maximum sensitivity of phase dual-slopes is at a depth of ~11 mm, which approaches the depth of cortical tissue.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11226, Neural Imaging and Sensing 2020, 1122607 (9 March 2020); doi: 10.1117/12.2545188
Show Author Affiliations
Sergio Fantini, Tufts Univ. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Giles Blaney, Tufts Univ. (United States)
Thao Pham, Tufts Univ. (United States)
Cristianne Fernandez, Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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