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Proceedings Paper

Biphasic response of LED photobiomodulation measured in vivo on human forearms with near-infrared spectroscopy (Conference Presentation)
Author(s): Ben Mattison; Paul Mathews; Peter Brawn

Paper Abstract

Photobiomodulation (PBM) treatment using light-emitting diodes (LEDs) has become an attractive alternative to using lasers in recent years. Two arrays of 54 LEDs at 850 nm were used to apply PBM at three different irradiances for 5 minutes to the forearms of 11 human subjects in a placebo-controlled experiment. Near-infrared spectroscopy was used in vivo to track changes in hemoglobin and mitochondrial markers over the course of the treatments. A non-linear biphasic response in these markers was observed with respect to irradiance and time, which suggests that there is an optimal dosimetry for PBM treatment as theorized by the Arndt-Schultz Law.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11221, Mechanisms of Photobiomodulation Therapy XV, 112210J (10 March 2020); doi: 10.1117/12.2545181
Show Author Affiliations
Ben Mattison, Biolux Research Ltd. (Canada)
Paul Mathews, Biolux Research Ltd. (Canada)
Peter Brawn, Biolux Research Ltd. (Canada)

Published in SPIE Proceedings Vol. 11221:
Mechanisms of Photobiomodulation Therapy XV
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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