Share Email Print
cover

Proceedings Paper

Fluorescence Lifetime Imaging (FLIm) for intraoperative pathology detection in transoral robotic surgery (Conference Presentation)
Author(s): Brent W. Weyers; Mark Marsden; Tianchen Sun; Julien Bec; Arnaud F. Bewley; Regina F. Gandour-Edwards; Michael G. Moore; D. Gregory Farwell; Laura Marcu

Paper Abstract

In this work, we evaluate the potential for Fluorescence Lifetime Imaging (FLIm) to complement a surgeon's visual, endoscopic, and pathologic assessment of the adequacy of intraoperative tumor resection in clinical cancer applications of the oral cavity and oropharynx. Using a custom-built FLIm instrument during both non-robotic and robotic assisted surgical procedures, we show that intrapatient contrast between healthy and tumor tissue can be achieved intraoperatively in vivo prior to cancer resection with statistical significance (p<0.001) in 9/9 patients using at least 1/6 FLIm parameters, and ex vivo for surgically excised specimens (p<0.001) for 8/9 patients. We employ a multi-parameter linear discriminant analysis approach to demonstrate superior pathology discrimination ability through leveraging a weighted combination of all FLIm metrics. We also highlight interpatient comparisons to evaluate how FLIm signatures vary across different patients and disparate tissue anatomies.

Paper Details

Date Published: 9 March 2020
PDF
Proc. SPIE 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII, 1122902 (9 March 2020); doi: 10.1117/12.2545150
Show Author Affiliations
Brent W. Weyers, Univ. of California, Davis (United States)
Mark Marsden, Univ. of California, Davis (United States)
Tianchen Sun, Univ. of California, Davis (United States)
Julien Bec, Univ. of California, Davis (United States)
Arnaud F. Bewley, UC Davis Medical Ctr. (United States)
Regina F. Gandour-Edwards, UC Davis Medical Ctr. (United States)
Michael G. Moore, UC Davis Medical Ctr. (United States)
D. Gregory Farwell, UC Davis Medical Ctr. (United States)
Laura Marcu, UC Davis Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 11229:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII
Anita Mahadevan-Jansen, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray