Share Email Print
cover

Proceedings Paper

New materials for laser welding of connective tissue and controlled release of antimicrobial principles
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Stitches or adhesive patches still represent the gold standard for the closure of wounds. However, inspite of their long history and widespread implementation, these solutions remain problematic in different respects, due to the combination of factors that complicate the healing process, such as foreign body reactions, antimicrobial infections, or the permeability of the repair. Our work consists of the pursuit of an alternative technological platform to seal wounds in different clinical contexts, by the use of laser welding in combination with biocompatible scaffolds made of electrospun fibers containing polysaccharidic components and hosting a variety of dyes, such as FDA-approved indocyanine green or more durable plasmonic nanoparticles. We illustrate the use of these materials in different regimes of optical irradiation, where cw light activates a cascade of photo-thermal and biochemical processes that result into a strong adhesion at the boundary with a connective tissue. We suggest the incorporation of multishell Au@Ag core@shell nanoparticles as a tool serving both as a photothermal transducer and a source of silver cations, which may migrate through the microporous scaffold and exert an antimicrobial function. While the versatility of our materials and methods still leaves substantial room for optimization and even more functionalization, we are confident that our work will make an impact and inspire new synergistic solutions at the crossroads between tissue engineering and biomedical optics.

Paper Details

Date Published: 19 February 2020
PDF: 5 pages
Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230S (19 February 2020); doi: 10.1117/12.2545141
Show Author Affiliations
Fulvio Ratto, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Annalisa Aluigi, Istituto per la Sintesi Organica e la Fotoreattività, CNR (Italy)
Sonia Centi, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Alessio Milanesi, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Boris Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Nikolai Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Vania Delfino, Univ. degli Studi di Firenze (Italy)
Carmela Calonico, Univ. degli Studi di Firenze (Italy)
Antonella Lo Nostro, Univ. degli Studi di Firenze (Italy)
Giada Magni, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Claudia Borri, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Lucia Cavigli, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Paolo Matteini, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Roberto Pini, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)
Francesca Rossi, Istituto di Fisica Applicata "Nello Carrara", CNR (Italy)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray