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Proceedings Paper

Fiber based black-body radiation thermal sensing for laser interstitial thermal therapy
Author(s): Paris Franz; Hui Wang
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Paper Abstract

Laser interstitial thermal therapy (LITT) has received increased interest in recent years, especially for treating neurological disorders such as gliomas and epilepsy. In LITT, monitoring tissue temperature is critical. For hyperthermia treatment of tumors, temperature must be controlled between 43 – 45°C to kill cancer cells through apoptosis. Heating tissue to higher temperatures between 50 – 80°C will quickly coagulate the tissue through necrosis. The success of LITT depends on accurate real-time temperature feedback. The advance of magnetic resonance imaging (MRI) thermometry has greatly enabled LITT for neurosurgery. However, the FDA has recently warned that MRI thermometry has a slow response time, which may lead to overtreatment. Here, we report our progress in developing a thermal sensing system based on blackbody radiation in the short-wave infrared range (SWIR, 1 μm – 2.5 μm) through a 2 m silica fiber to monitor temperatures as low as 40°C. In the SWIR range, water absorption and silica fiber attenuation are relatively low, making tissue temperature measurement feasible during LITT. We demonstrate the feasibility of using SWIR blackbody radiation for real-time temperature monitoring through bench-top studies and ex vivo tissue studies. This new thermal sensing technology could be seamlessly integrated with current MRI thermometry to improve response time. It could also be used standalone during LITT for applications when use of MRI thermometry is not feasible.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII, 1122911 (21 February 2020); doi: 10.1117/12.2545132
Show Author Affiliations
Paris Franz, Miami Univ. (United States)
Stanford Univ. (United States)
Hui Wang, Miami Univ. (United States)


Published in SPIE Proceedings Vol. 11229:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII
Anita Mahadevan-Jansen, Editor(s)

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