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Proceedings Paper

Particle sensing with confined optical field enhanced fluorescence emission (Conference Presentation)
Author(s): Shamsul Abedin; Christian Vargas; Eric O. Potma

Paper Abstract

A surface plasmon resonance (SPR) based optical sensor is developed for real-time measurement of nano-scale binding events near a gold surface. The system, which we call confined optical field enhanced fluorescence emission (Cofefe), replaces the cw laser used in SPR devices by a femtosecond source, allowing for the generation and detection of optical non-linearities at the sensor surface. The binding events show up in the detector as diffraction limited spots against a dark background. We also demonstrate that the sensor can reliably register DNA hybridization adsorption events without any bright background or interference patterns that plague the traditional SPRI systems.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 112570P (10 March 2020); doi: 10.1117/12.2545129
Show Author Affiliations
Shamsul Abedin, Univ. of California, Irvine (United States)
Christian Vargas, Univ. of California, Irvine (United States)
Eric O. Potma, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 11257:
Plasmonics in Biology and Medicine XVII
Tuan Vo-Dinh; Ho-Pui A. Ho; Krishanu Ray, Editor(s)

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