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Proceedings Paper

Laser speckle micro-rheology for biomechanical profiling of breast cancer (Conference Presentation)
Author(s): Zeinab Hajjarian Kashany; Elena F. Brachtel; Diane M. Tshikudi; Seemantini K. Nadkarni

Paper Abstract

Breast neoplasia is accompanied by a heterogeneous micromechanical remodeling of the tumor landscape. Nevertheless, the role of these micromechanical heterogeneities in the progression of invasive breast carcinoma remains unclear. We have developed a novel optical tool, termed laser speckle microrheology (LSM) for micro-mechanical mapping of the tissue to investigate mechano-pathological features of breast cancer progression. Results reveal distinct micromechanical properties both between tumor of different diagnosis and within various regions of each tumor. Additionally, distinct stiffness gradients are observed at the interface of tumors with different invasive potential. Taken together, these findings identify key micromechanical features involved in breast cancer progression.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 112420D (9 March 2020); doi: 10.1117/12.2545055
Show Author Affiliations
Zeinab Hajjarian Kashany, Harvard Medical School (United States)
Elena F. Brachtel, Harvard Medical School (United States)
Diane M. Tshikudi, Harvard Medical School (United States)
Seemantini K. Nadkarni, Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 11242:
Optical Elastography and Tissue Biomechanics VII
Kirill V. Larin; Giuliano Scarcelli, Editor(s)

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